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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgfr
Name: prostaglandin F receptor
Acc ID: CHEBI:15553
Term: prostaglandin F2alpha
Definition: A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.
Chemical ID: MESH:D015237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgfrincreases expressionEXP 6480464CTDDinoprost results in increased expression of PTGFR mRNAPMID:11517196
Ptgfrmultiple interactionsISOPtgfr (Mus musculus)6480464CTD[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]PMID:22583689
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