Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3423
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Psap
Name:	prosaposin

Acc ID:	CHEBI:46195
Term:	paracetamol
Definition:	A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID:	MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Psap	increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of PSAP mRNA	PMID:33387578
Psap	affects expression	ISO	Psap (Mus musculus)	6480464	CTD	Acetaminophen affects the expression of PSAP mRNA	PMID:17562736
Psap	increases expression	ISO	PSAP (Homo sapiens)	6480464	CTD	Acetaminophen results in increased expression of PSAP mRNA	PMID:25704631
Psap	multiple interactions	ISO	Psap (Mus musculus)	6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA]	PMID:17585979
Psap	multiple interactions	ISO	PSAP (Homo sapiens)	6480464	CTD	[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of PSAP mRNA	PMID:17093179

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