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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prlincreases expressionISOPRL (Homo sapiens)6480464CTDVerapamil results in increased expression of PRL proteinPMID:8845563 PMID:8977754
Prlincreases secretionISOPRL (Homo sapiens)6480464CTDVerapamil results in increased secretion of PRL proteinPMID:20595935
Prlmultiple interactionsISOPRL (Homo sapiens)6480464CTDVerapamil inhibits the reaction [Sulpiride results in increased secretion of PRL protein]; Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]PMID:7851873
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