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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3389
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkacadecreases expressionISOPrkaca (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of PRKACA proteinPMID:33234378
Prkacadecreases phosphorylationISOPrkaca (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased phosphorylation of PRKACA proteinPMID:32303808
Prkacamultiple interactionsISOPrkaca (Mus musculus)6480464CTDColforsin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of PRKACA protein]; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of PRKACA protein]; PDE3A mRNA promotes the reaction [Diethylhexyl Phthalate results in decreased expression of PRKACA protein]PMID:32303808 PMID:33234378
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