GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pparg | affects binding | ISO | PPARG (Homo sapiens) | 6480464 | CTD | sulindac sulfide analog binds to PPARG protein | PMID:18665581 | Pparg | increases activity | ISO | PPARG (Homo sapiens) | 6480464 | CTD | sulindac sulfide results in increased activity of PPARG protein | PMID:10866999 | Pparg | increases expression | ISO | PPARG (Homo sapiens) | 6480464 | CTD | sulindac sulfide results in increased expression of PPARG mRNA | PMID:11948457 | Pparg | multiple interactions | ISO | PPARG (Homo sapiens) | 6480464 | CTD | [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide analog binds to and results in increased activity of PPARG protein; sulindac sulfide analog inhibits the reaction [troglitazone binds to PPARG protein]; sulindac sulfide binds to and results in increased activity of PPARG protein | PMID:10866999 PMID:16091736 PMID:17602619 PMID:18665581 | | ||||||||||||||||||||||
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