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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pomc
Name: proopiomelanocortin
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pomcaffects expressionEXP 6480464CTDNicotine affects the expression of POMC proteinPMID:22975262
Pomcdecreases expressionEXP 6480464CTDNicotine results in decreased expression of POMC proteinPMID:28555334
Pomcincreases expressionEXP 6480464CTDNicotine results in increased expression of POMC protein alternative formPMID:23623838
Pomcaffects response to substanceISOPomc (Mus musculus)6480464CTDPOMC protein affects the susceptibility to NicotinePMID:19376143
Pomcmultiple interactionsISOPomc (Mus musculus)6480464CTDPOMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]PMID:15689546
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