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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3336
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pklr
Name: pyruvate kinase L/R
Acc ID: CHEBI:32509
Term: pirinixic acid
Definition: An aryl sulfide that has formula C14H14ClN3O2S.
Chemical ID: MESH:C006253
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pklraffects expressionEXP 6480464CTDpirinixic acid affects the expression of PKLR mRNAPMID:19483382
Pklrdecreases expressionEXP 6480464CTDpirinixic acid results in decreased expression of PKLR mRNAPMID:16644726 PMID:19162173 PMID:22484513
Pklrmultiple interactionsEXP 6480464CTDMLXIPL protein inhibits the reaction [pirinixic acid results in decreased expression of PKLR mRNA]; pirinixic acid inhibits the reaction [Glucose results in increased activity of PKLR protein]; pirinixic acid inhibits the reaction [Glucose results in increased expression of PKLR mRNA]PMID:16644726
Pklrdecreases expressionISOPklr (Mus musculus)6480464CTDpirinixic acid results in decreased expression of PKLR mRNAPMID:16807375 PMID:17426115 PMID:18620774 PMID:20059764 PMID:20813756 PMID:23811191
Pklrmultiple interactionsISOPklr (Mus musculus)6480464CTD[pirinixic acid co-treated with PPARA] results in decreased expression of PKLR mRNA; pirinixic acid inhibits the reaction [Ethanol results in increased expression of PKLR mRNA]; PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PKLR mRNA]PMID:18620774 PMID:20059764 PMID:20813756
Pklrmultiple interactionsISOPKLR (Homo sapiens)6480464CTD[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PKLR mRNAPMID:19710929
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