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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:78782
Term: pyrrolidine dithiocarbamate
Definition: A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine.
Chemical ID: MESH:C020972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1increases expressionISOSERPINE1 (Homo sapiens)6480464CTDpyrrolidine dithiocarbamic acid results in increased expression of SERPINE1 mRNAPMID:12719791
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTDpyrrolidine dithiocarbamic acid inhibits the reaction [RAC1 protein inhibits the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]]; pyrrolidine dithiocarbamic acid inhibits the reaction [RAC1 protein results in decreased expression of SERPINE1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Oxygen deficiency results in increased expression of SERPINE1 mRNA]PMID:12719791
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