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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3197
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Npy
Name: neuropeptide Y
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Npyincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of NPY mRNA; Chlorpyrifos results in increased expression of NPY proteinPMID:20682304 PMID:26775027
Npymultiple interactionsISONPY (Homo sapiens)6480464CTD[APOE gene polymorphism affects the susceptibility to Chlorpyrifos] which affects the expression of NPY mRNAPMID:31472362
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