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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:84491
Term: poly(I:C)
Definition: A mismatched double-stranded RNA with one strand being a polymer of inosinic acid, the other a polymer of cytidylic acid.
Chemical ID: MESH:D011070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases expressionEXP 6480464CTDPoly I-C results in increased expression of NOS2 mRNAPMID:23939143
Nos2multiple interactionsEXP 6480464CTDDiclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]PMID:23939143
Nos2increases expressionISONos2 (Mus musculus)6480464CTDPoly I-C results in increased expression of NOS2 mRNA; Poly I-C results in increased expression of NOS2 proteinPMID:17321468 PMID:18323514 PMID:21195166 PMID:30726814
Nos2multiple interactionsISONos2 (Mus musculus)6480464CTDpitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]PMID:18279804 PMID:18323514 PMID:30726814
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