GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | affects expression | EXP | | 6480464 | CTD | Doxorubicin affects the expression of NOS2 mRNA | PMID:12187937 | Nos2 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of NOS2 mRNA; Doxorubicin results in increased expression of NOS2 protein | PMID:17223128 PMID:17582587 PMID:20051877 PMID:20668052 PMID:25411067 PMID:28815802 PMID:29315967 PMID:30142312 PMID:30836069 PMID:35843304 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | [Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of NOS2 mRNA; [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; caryophyllene inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Drugs, Chinese Herbal inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Ellagic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; erucic acid promotes the reaction [Doxorubicin results in increased expression of NOS2 protein]; galangin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]]; Lisinopril inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; N-benzyladriamycin-14-valerate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; oleuropein inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein] | PMID:17223128 PMID:17582587 PMID:20051877 PMID:20668052 PMID:25411067 PMID:27181935 PMID:28815802 PMID:29315967 PMID:30142312 PMID:30836069 PMID:35843304 | Nos2 | decreases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of NOS2 mRNA | PMID:29803840 | Nos2 | decreases response to substance | ISO | Nos2 (Mus musculus) | 6480464 | CTD | NOS2 protein results in decreased susceptibility to Doxorubicin | PMID:19286953 | Nos2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of NOS2 mRNA; Doxorubicin results in increased expression of NOS2 protein | PMID:10871338 PMID:12490132 PMID:19286953 PMID:21443895 PMID:29775573 PMID:32068018 PMID:37409694 | Nos2 | increases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of NOS2 mRNA; Doxorubicin results in increased expression of NOS2 protein | PMID:15695394 PMID:18463201 | Nos2 | increases response to substance | ISO | Nos2 (Mus musculus) | 6480464 | CTD | NOS2 protein results in increased susceptibility to Doxorubicin | PMID:12591762 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | [Vancomycin co-treated with Neomycin co-treated with Cilastatin, Imipenem Drug Combination] inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Cilastatin, Imipenem Drug Combination] inhibits the reaction [Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of NOS2 mRNA]]; BDKRB1 protein affects the reaction [Doxorubicin results in increased expression of NOS2 protein]; BDKRB2 protein affects the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; IL1B protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of NOS2 mRNA]; indole-3-carbinol inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; TNF protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of NOS2 mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA] | PMID:12490132 PMID:21443895 PMID:29775573 PMID:32068018 PMID:37409694 | Nos2 | multiple interactions | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Simvastatin promotes the reaction [Doxorubicin results in increased expression of NOS2 protein] | PMID:18463201 | | ||||||||||||||||||||||
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