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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3172
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfyb
Name: nuclear transcription factor Y subunit beta
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfybaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of NFYB mRNAPMID:22298810
Nfybdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of NFYB mRNAPMID:21215274 PMID:33387578
Nfybincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of NFYB mRNAPMID:34747641
Nfybaffects expressionISONfyb (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of NFYB mRNAPMID:21570461 PMID:24058054
Nfybdecreases expressionISONfyb (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of NFYB mRNAPMID:16214954 PMID:18796159 PMID:26290441
Nfybmultiple interactionsISONfyb (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NFYB mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of NFYB mRNA; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NFYB mRNA]PMID:16214954 PMID:17942748 PMID:25975270
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