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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3111
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mras
Name: muscle RAS oncogene homolog
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mrasdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of MRAS mRNAPMID:34747641
Mrasincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of MRAS mRNAPMID:27913140
Mrasaffects expressionISOMras (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MRAS mRNAPMID:21570461
Mrasdecreases expressionISOMras (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MRAS mRNAPMID:19933214
Mrasincreases expressionISOMRAS (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of MRAS mRNAPMID:20106945 PMID:21632981
Mrasmultiple interactionsISOMras (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin affects the methylation of MRAS intron] which results in decreased expression of MRAS mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRAS mRNAPMID:17942748 PMID:33017471
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