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GENE - TERM ANNOTATION REPORT

RGD ID: 3098
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mme
Name: membrane metallo-endopeptidase
Acc ID: DOID:10976
Term: membranous glomerulonephritis
Definition: A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Definition Source(s): MESH:D015433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mme ISOMME (Homo sapiens)1600817RGDantenatal membranous glomerulonephritis 
Mme ISOMME (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunizationPMID:15464186 PMID:24033266 PMID:25565308 PMID:25741868 PMID:26991897 PMID:27588448 PMID:28492532 PMID:30415211
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