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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:10110
Term: zidovudine
Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
Chemical ID: MESH:D015215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Me1decreases expressionISOMe1 (Mus musculus)6480464CTDZidovudine results in decreased expression of ME1 mRNAPMID:11741158
Me1multiple interactionsISOMe1 (Mus musculus)6480464CTD[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of ME1 mRNA; [Zidovudine co-treated with Lamivudine] affects the expression of ME1 mRNAPMID:11741158
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