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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3054
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mbp
Name: myelin basic protein
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mbpdecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of MBP mRNA; Streptozocin results in decreased expression of MBP proteinPMID:20349157 PMID:38049026
Mbpmultiple interactionsEXP 6480464CTD20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA]; Progesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA]; Vitamin B 12 inhibits the reaction [Streptozocin results in decreased expression of MBP protein]PMID:20349157 PMID:38049026
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