Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3046
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Mapk3
Name:	mitogen activated protein kinase 3

Acc ID:	CHEBI:77543
Term:	ebselen
Definition:	A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.
Chemical ID:	MESH:C042986

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mapk3	increases activity	EXP		6480464	CTD	ebselen results in increased activity of MAPK3 protein	PMID:21960664
Mapk3	increases phosphorylation	EXP		6480464	CTD	ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein	PMID:22001386 PMID:27282967
Mapk3	multiple interactions	EXP		6480464	CTD	ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]	PMID:20495008 PMID:21300091
Mapk3	multiple interactions	ISO	Mapk3 (Mus musculus)	6480464	CTD	ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]	PMID:20495008

Go Back to source page

Continue to Ontology report