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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3046
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen activated protein kinase 3
Acc ID: CHEBI:17183
Term: sanguinarine
Definition: A botanical anti-fungal agent that has formula C20H14NO4.
Chemical ID: MESH:C005705
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationISOMAPK3 (Homo sapiens)6480464CTDsanguinarine results in increased phosphorylation of MAPK3 proteinPMID:19135517
Mapk3multiple interactionsISOMAPK3 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; sanguinarine inhibits the reaction [Roflumilast inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]]; sanguinarine promotes the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein]PMID:19135517 PMID:39197814
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