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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:5692
Term: hexachlorobenzene
Definition: A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID: MESH:D006581
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3increases phosphorylationISOSmad3 (Mus musculus)6480464CTDHexachlorobenzene results in increased phosphorylation of SMAD3 proteinPMID:28923513
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTDAG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; Hexachlorobenzene results in increased phosphorylation of and affects the localization of SMAD3 proteinPMID:27519288
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