GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of SMAD3 mRNA | PMID:33387578 | Smad3 | affects expression | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA | PMID:21570461 | Smad3 | affects phosphorylation | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein | PMID:31887333 | Smad3 | increases expression | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA | PMID:24058054 | Smad3 | multiple interactions | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein] | PMID:31887333 | Smad3 | multiple interactions | ISO | Smad3 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SMAD3 mRNA | PMID:17942748 PMID:25975270 | | ||||||||||||||||||||||
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