GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | increases activity | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased activity of SMAD3 protein | PMID:17009398 | Smad3 | increases expression | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased expression of SMAD3 mRNA; Carbon Tetrachloride results in increased expression of SMAD3 protein | PMID:15818738 PMID:16872305 PMID:17163593 | Smad3 | increases phosphorylation | EXP | | 6480464 | CTD | Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein | PMID:24211420 PMID:25150141 | Smad3 | multiple interactions | EXP | | 6480464 | CTD | [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]; methyl ferulate inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein]; Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] | PMID:15818738 PMID:16872305 PMID:17163593 PMID:30543783 | Smad3 | affects response to substance | ISO | Smad3 (Mus musculus) | 6480464 | CTD | SMAD3 protein affects the susceptibility to Carbon Tetrachloride | PMID:16382155 | Smad3 | increases expression | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of SMAD3 mRNA; Carbon Tetrachloride results in increased expression of SMAD3 protein | PMID:18395914 PMID:26297989 PMID:33309619 | Smad3 | increases phosphorylation | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein | PMID:26337812 PMID:34029542 PMID:36368619 | Smad3 | multiple interactions | ISO | Smad3 (Mus musculus) | 6480464 | CTD | Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein]; chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein]; oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; phyllanthin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]; Silymarin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] | PMID:18395096 PMID:18395914 PMID:26297989 PMID:26337812 PMID:33309619 PMID:34029542 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |