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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj6multiple interactionsEXP 6480464CTDEthanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]; Ethosuximide inhibits the reaction [Ethanol promotes the reaction [[KCNJ3 protein binds to KCNJ6 protein] which results in increased transport of Potassium]]PMID:18977371
Kcnj6increases activityISOKcnj6 (Mus musculus)6480464CTDEthanol results in increased activity of KCNJ6 proteinPMID:16626657
Kcnj6multiple interactionsISOKcnj6 (Mus musculus)6480464CTDEthanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]; Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]PMID:22164246
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