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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:66919
Term: ruxolitinib
Definition: A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis.
Chemical ID: MESH:C540383
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2affects response to substanceISOJAK2 (Homo sapiens)6480464CTDJAK2 gene mutant form affects the susceptibility to ruxolitinibPMID:26300391
Jak2decreases activityISOJAK2 (Homo sapiens)6480464CTDruxolitinib results in decreased activity of JAK2 proteinPMID:24883332 PMID:26300391
Jak2multiple interactionsISOJAK2 (Homo sapiens)6480464CTD[ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of JAK2 proteinPMID:30012499
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