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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2939
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2decreases expressionEXP 6480464CTDNicotine results in decreased expression of JAK2 mRNAPMID:29155039
Jak2increases phosphorylationEXP 6480464CTDNicotine results in increased phosphorylation of JAK2 proteinPMID:34153408
Jak2multiple interactionsEXP 6480464CTDBungarotoxins inhibits the reaction [Nicotine results in increased phosphorylation of JAK2 protein]PMID:34153408
Jak2increases response to substanceISOJAK2 (Homo sapiens)6480464CTDJAK2 results in increased susceptibility to NicotinePMID:20943775
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