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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2926
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itgam
Name: integrin subunit alpha M
Acc ID: CHEBI:36707
Term: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Definition: A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl group is specified as acetyl; a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Chemical ID: MESH:D010972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itgamincreases expressionISOITGAM (Homo sapiens)6480464CTDPlatelet Activating Factor results in increased expression of ITGAM proteinPMID:11116075 PMID:9762784
Itgammultiple interactionsISOITGAM (Homo sapiens)6480464CTDForopafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]PMID:11116075 PMID:9762784
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