An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID:
MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
4-hydroxyisoleucine inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; 4-methyl-2-((2-methylbenzyl) amino)-1,3-thiazole-5-carboxylic acid inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in increased secretion of INS1 protein; [Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein; [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]; [INS1 protein co-treated with Pravastatin] inhibits the reaction [Streptozocin results in increased expression of ACE protein]; [Niacinamide co-treated with Streptozocin] results in decreased expression of INS1 protein; [Plant Extracts co-treated with glimepiride] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; [Propolis co-treated with Chlorpyrifos] inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; [Propolis co-treated with Streptozocin co-treated with Chlorpyrifos] results in decreased secretion of INS1 protein; [Propolis co-treated with Streptozocin] promotes the reaction [Chlorpyrifos results in decreased expression of INS1 protein]; [Propolis co-treated with Streptozocin] promotes the reaction [Chlorpyrifos results in decreased secretion of INS1 protein]; [Propolis co-treated with Streptozocin] results in decreased secretion of INS1 protein; [Streptozocin co-treated with Cadmium] results in decreased expression of INS1 protein; [Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein; [Streptozocin co-treated with Fructose] results in increased expression of INS1 protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein; [Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein; [Streptozocin co-treated with Niacinamide] results in increased expression of INS1 protein; [Streptozocin co-treated with Sodium Glutamate] results in decreased expression of INS1 protein; Acetates inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of INS1 protein]; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]]; anthranilic acid analog inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; bisacurone inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; Butyric Acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; caryophyllene inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; chebulagic acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Chlorpyrifos inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; citronellol inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; corilagin inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]; costunolide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased expression of INS1 protein]; coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of INS1 protein]; crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; Diosgenin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Estradiol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of INS1 protein]; Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]; geraniol inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; glimepiride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased secretion of INS1 protein]; Imatinib Mesylate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of SLC1A3 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased activity of CAT protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of COL3A1 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CYP8B1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of MMP2 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of MMP9 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Lithium Carbonate inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; mangiferin inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Melatonin affects the reaction [Streptozocin results in decreased expression of INS1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]; morin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of INS1 protein]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; nerolidol inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; palbinone inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Pioglitazone inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of INS1 protein]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of INS1 protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein]; Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Plant Extracts inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; plumbagin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Polysaccharides inhibits the reaction [Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein]; Propolis inhibits the reaction [[Streptozocin co-treated with Chlorpyrifos] results in decreased secretion of INS1 protein]; Propolis inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of INS1 protein]; repaglinide analog affects the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; repaglinide inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein]; rhapontin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Rosiglitazone promotes the reaction [Streptozocin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]]; S-allylcysteine inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Streptozocin affects the reaction [Chlorpyrifos results in decreased secretion of INS1 protein]; Streptozocin inhibits the reaction [Blood Glucose results in increased secretion of INS1 protein]; Streptozocin inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]; Streptozocin promotes the reaction [Dietary Fats results in increased expression of INS1 protein]; Streptozocin results in decreased expression of and results in decreased secretion of INS1 protein; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of INS1 protein]; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased secretion of INS1 protein]; TRH protein inhibits the reaction [Streptozocin inhibits the reaction [Blood Glucose results in increased secretion of INS1 protein]]; Tribulus extract inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased secretion of INS1 protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein]
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein]; [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein; [Streptozocin co-treated with Dietary Fats co-treated with Diethylhexyl Phthalate] results in increased expression of INS1 protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of INS1 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA; AM 251 inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; bisphenol A inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Carnosine inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; CNR1 protein promotes the reaction [Streptozocin results in decreased expression of INS1 protein]; Dronabinol inhibits the reaction [Streptozocin results in decreased expression of INS1]; Edaravone inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 mRNA]; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine]; INS1 protein affects the reaction [Streptozocin results in decreased methylation of PPP2CA protein]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of POU1F1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of POU1F1 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of SLC20A2 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of SLC20A2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; octylphenol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; PQQ Cofactor inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]; Streptozocin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; sulforaphane inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; tianhuang inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]
