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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:28790
Term: serotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Chemical ID: MESH:D012701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects expressionISOIL6 (Homo sapiens)6480464CTDSerotonin affects the expression of IL6 mRNAPMID:15802305
Il6affects secretionISOIL6 (Homo sapiens)6480464CTDSerotonin affects the secretion of IL6 proteinPMID:15802305
Il6increases expressionISOIl6 (Mus musculus)6480464CTDSerotonin results in increased expression of IL6PMID:15302781
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDSerotonin results in increased expression of IL6 mRNAPMID:11076827
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTDanandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]PMID:30611738
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 proteinPMID:11076827
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