GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il6 | affects expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Serotonin affects the expression of IL6 mRNA | PMID:15802305 | Il6 | affects secretion | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Serotonin affects the secretion of IL6 protein | PMID:15802305 | Il6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Serotonin results in increased expression of IL6 | PMID:15302781 | Il6 | increases expression | ISO | IL6 (Homo sapiens) | 6480464 | CTD | Serotonin results in increased expression of IL6 mRNA | PMID:11076827 | Il6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | anandamide inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; glyceryl 2-arachidonate inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; GR 113808 inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Granisetron inhibits the reaction [Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]]; Serotonin promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein] | PMID:30611738 | Il6 | multiple interactions | ISO | IL6 (Homo sapiens) | 6480464 | CTD | [Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein; calphostin C inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]; Serotonin results in increased expression of and results in increased secretion of IL6 protein | PMID:11076827 | | ||||||||||||||||||||||
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