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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:181932
Term: 3-Nitrobenzanthrone
Definition: null
Chemical ID: MESH:C117220
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases expressionISOIL6 (Homo sapiens)6480464CTD3-nitrobenzanthrone results in increased expression of IL6 mRNAPMID:34036453
Il6increases secretionISOIL6 (Homo sapiens)6480464CTD3-nitrobenzanthrone results in increased secretion of IL6 proteinPMID:34036453
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDIL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK1 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of MAPK3 protein]; IL6 protein affects the reaction [3-nitrobenzanthrone results in increased phosphorylation of STAT3 protein]PMID:34036453
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