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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:6923
Term: miconazole
Definition: A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Chemical ID: MESH:D008825
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4decreases expressionISOIL4 (Homo sapiens)6480464CTDMiconazole results in decreased expression of IL4 mRNAPMID:11886533 PMID:15284827
Il4decreases secretionISOIL4 (Homo sapiens)6480464CTDMiconazole results in decreased secretion of IL4 proteinPMID:11886533 PMID:15284827
Il4multiple interactionsISOIL4 (Homo sapiens)6480464CTD1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Miconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Miconazole results in decreased secretion of IL4 protein]PMID:11886533
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