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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:46680
Term: serpentine asbestos
Definition: null
Chemical ID: MESH:D017632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4increases expressionISOIl4 (Mus musculus)6480464CTDAsbestos, Serpentine results in increased expression of IL4 mRNA; Asbestos, Serpentine results in increased expression of IL4 proteinPMID:16251409 PMID:17200189 PMID:21514415
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDPRKDC affects the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]; PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of IL4 mRNA]; SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of IL4 protein]PMID:17200189 PMID:21514415
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