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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:38940
Term: sunitinib
Definition: A pyrrole that has formula C22H27FN4O2.
Chemical ID: MESH:C473478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTDSunitinib inhibits the reaction [IL4 protein results in increased expression of ARG1 protein]; Sunitinib inhibits the reaction [IL4 protein results in increased expression of IL10 protein]; Sunitinib inhibits the reaction [IL4 protein results in increased expression of MPZ protein]; Sunitinib inhibits the reaction [IL4 protein results in increased expression of MRC1 protein]; Sunitinib inhibits the reaction [IL4 protein results in increased expression of VEGFA protein]; Sunitinib inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]; Sunitinib inhibits the reaction [IL4 protein results in increased phosphorylation of STAT6 protein]PMID:36797997
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