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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:3020
Term: benzalkonium chloride
Definition: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.
Chemical ID: MESH:D001548
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4increases expressionISOIl4 (Mus musculus)6480464CTDBenzalkonium Compounds results in increased expression of IL4 proteinPMID:30517752
Il4multiple interactionsISOIl4 (Mus musculus)6480464CTD[IL6RA gene mutant form results in increased susceptibility to Benzalkonium Compounds] which results in decreased expression of IL4 proteinPMID:31158415
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