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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1r1
Name: interleukin 1 receptor type 1
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1r1increases expressionEXP 6480464CTDNicotine results in increased expression of IL1R1 mRNA; Nicotine results in increased expression of IL1R1 proteinPMID:27180639
Il1r1multiple interactionsEXP 6480464CTDmethyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 mRNA]; methyllycaconitine affects the reaction [Nicotine results in increased expression of IL1R1 protein]PMID:27180639
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