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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDochratoxin A results in increased expression of IL1B mRNAPMID:24792326
Il1bincreases expressionISOIl1b (Mus musculus)6480464CTDochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B proteinPMID:28710020 PMID:33543323
Il1bincreases secretionISOIL1B (Homo sapiens)6480464CTDochratoxin A results in increased secretion of IL1B proteinPMID:38301823
Il1bmultiple interactionsISOIl1b (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with ochratoxin A] results in increased expression of IL1B protein; [ochratoxin A results in increased susceptibility to Antigens] which results in increased expression of IL1B protein; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; sulforaphane inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]PMID:28710020 PMID:28935500
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDochratoxin A inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; ochratoxin A inhibits the reaction [IL1B protein results in increased expression of F3 protein]PMID:18289624 PMID:18308354
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