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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bmultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Diclofenac promotes the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]PMID:10541287 PMID:19393675 PMID:23395999
Il1bdecreases response to substanceISOIL1B (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to IL1B proteinPMID:14581482
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of IL1B protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL1B protein]; sodium arsenite inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with IL1B protein] results in increased expression of and results in increased phosphorylation of NFKBIA protein]PMID:11835394 PMID:14581482 PMID:34920032
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