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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2891
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:15647
Term: leukotriene B4
Definition: A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.
Chemical ID: MESH:D007975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases abundanceISOIL1B (Homo sapiens)6480464CTDIL1B protein results in increased abundance of Leukotriene B4PMID:18759268
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDresveratrol inhibits the reaction [IL1B protein results in increased abundance of Leukotriene B4]PMID:18759268
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