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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2874
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp3
Name: insulin-like growth factor binding protein 3
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp3increases expressionISOIgfbp3 (Mus musculus)6480464CTDStreptozocin results in increased expression of IGFBP3 mRNAPMID:29673160
Igfbp3multiple interactionsISOIgfbp3 (Mus musculus)6480464CTD2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of IGFBP3 mRNA]PMID:29673160
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