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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2872
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igfbp1
Name: insulin-like growth factor binding protein 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igfbp1decreases expressionISOIgfbp1 (Mus musculus)6480464CTDcobaltous chloride results in decreased expression of IGFBP1 mRNAPMID:21139344
Igfbp1increases expressionISOIgfbp1 (Mus musculus)6480464CTDcobaltous chloride results in increased expression of IGFBP1 mRNA; cobaltous chloride results in increased expression of IGFBP1 proteinPMID:16990490
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