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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2836
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd17b1
Name: hydroxysteroid (17-beta) dehydrogenase 1
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd17b1decreases expressionEXP 6480464CTDNicotine results in decreased expression of HSD17B1 mRNA; Nicotine results in decreased expression of HSD17B1 proteinPMID:20498001 PMID:30959089
Hsd17b1multiple interactionsEXP 6480464CTDTaurine inhibits the reaction [Nicotine results in decreased expression of HSD17B1 protein]PMID:20498001
Hsd17b1decreases expressionISOHSD17B1 (Homo sapiens)6480464CTDNicotine results in decreased expression of HSD17B1 mRNAPMID:30959089
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