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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hrh1
Name: histamine receptor H 1
Acc ID: CHEBI:291342
Term: desloratadine
Definition: Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
Chemical ID: MESH:C121345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrh1affects bindingISOHRH1 (Homo sapiens)6480464CTDdesloratadine binds to HRH1 proteinPMID:15482930
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