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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDthymoquinone results in increased expression of HMOX1 mRNA; thymoquinone results in increased expression of HMOX1 proteinPMID:24355171
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]PMID:24355171
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