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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionEXP 6480464CTDZinc Sulfate results in increased expression of HMOX1 mRNAPMID:17074742
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDZinc Sulfate results in increased expression of HMOX1 mRNAPMID:23085594
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDZinc Sulfate results in increased expression of HMOX1 mRNAPMID:16330358 PMID:17244614 PMID:32712770
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Disulfiram co-treated with Zinc Sulfate] results in increased expression of HMOX1 mRNA; [Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of HMOX1 mRNA; MTF1 protein affects the reaction [[Zinc Sulfate results in increased abundance of Zinc] which results in increased expression of HMOX1 mRNA]; Zinc Sulfate promotes the reaction [HSF1 protein binds to HMOX1 promoter]PMID:17244614 PMID:32661532 PMID:32712770
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