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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDFolic Acid results in increased expression of HMOX1 mRNA; Folic Acid results in increased expression of HMOX1 proteinPMID:25629700 PMID:35191561
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HMOX1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HMOX1 mRNA; [Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of HMOX1 protein]; Trimetazidine promotes the reaction [Folic Acid results in increased expression of HMOX1 protein]PMID:20938992 PMID:22206623 PMID:35191561 PMID:37263574
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD[Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of HMOX1 protein]PMID:37263574
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