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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:17549
Term: 5-aminolevulinic acid
Definition: The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.
Chemical ID: MESH:D000622
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases activityEXP 6480464CTDAminolevulinic Acid results in increased activity of HMOX1 proteinPMID:12853123
Hmox1multiple interactionsEXP 6480464CTDBilirubin inhibits the reaction [Aminolevulinic Acid results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Aminolevulinic Acid results in increased activity of HMOX1 protein]PMID:12853123
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDAminolevulinic Acid results in increased expression of HMOX1 mRNAPMID:22859313
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDNFE2L2 gene mutant form promotes the reaction [Aminolevulinic Acid results in increased expression of HMOX1 mRNA]PMID:22859313
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