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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16547
Term: coniferyl aldehyde
Definition: A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C075384
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDconiferaldehyde results in increased expression of HMOX1 proteinPMID:26275128
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDconiferaldehyde results in increased expression of HMOX1 mRNA; coniferaldehyde results in increased expression of HMOX1 proteinPMID:26275128
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPK14 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; PKN3 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; Ro 31-8220 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]PMID:26275128
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