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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:164200
Term: triclosan
Definition: An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards, sports equipment and shoes.
Chemical ID: MESH:D014260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDTriclosan results in increased expression of HMOX1 proteinPMID:34160118
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDTriclosan results in increased expression of HMOX1 mRNAPMID:30510588
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Triclosan results in increased expression of HMOX1 protein]PMID:34160118
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