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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1affects expressionEXP 6480464CTDQuercetin affects the expression of HMOX1 mRNAPMID:18178720
Hmox1increases expressionEXP 6480464CTDQuercetin results in increased expression of HMOX1 mRNA; Quercetin results in increased expression of HMOX1 proteinPMID:15118350 PMID:16303981 PMID:16647178 PMID:18602965 PMID:22056766 PMID:22535755 PMID:24331699 PMID:25716194 PMID:27166148
Hmox1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein; Cycloheximide inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Quercetin results in decreased susceptibility to Ethanol]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]]; Hydrogen Peroxide affects the reaction [Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 mRNA]; Quercetin affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]; Quercetin affects the reaction [Hydrogen Peroxide affects the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] affects the expression of HMOX1 protein]]; Quercetin inhibits the reaction [[Dietary Carbohydrates co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Quercetin inhibits the reaction [Cyclophosphamide results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [cypermethrin results in decreased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]; Quercetin inhibits the reaction [Paraquat results in increased expression of HMOX1]; Quercetin inhibits the reaction [Vincristine results in decreased activity of HMOX1 protein]; Quercetin inhibits the reaction [Vincristine results in decreased expression of HMOX1 protein]; Quercetin results in increased expression of and results in increased activity of HMOX1 protein; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]PMID:15118350 PMID:16647178 PMID:20600150 PMID:22056766 PMID:22535755 PMID:23770986 PMID:24331699 PMID:25716194 PMID:27028516 PMID:33038355 PMID:35876585 PMID:36808657 PMID:37419146
Hmox1increases activityISOHMOX1 (Homo sapiens)6480464CTDQuercetin results in increased activity of HMOX1 proteinPMID:17433488
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDQuercetin analog results in increased expression of HMOX1 mRNA; Quercetin analog results in increased expression of HMOX1 protein; Quercetin results in increased expression of HMOX1 mRNA; Quercetin results in increased expression of HMOX1 proteinPMID:14563492 PMID:15876423 PMID:16171798 PMID:20579867 PMID:21216973 PMID:22138401 PMID:23295412 PMID:24040572 PMID:25413579 PMID:26505893 PMID:27583449 PMID:27777014 PMID:36584933
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDQuercetin results in increased expression of HMOX1 mRNA; Quercetin results in increased expression of HMOX1 proteinPMID:16799064 PMID:17210444 PMID:19576171 PMID:21216973 PMID:21525764 PMID:22996356 PMID:25413579 PMID:25881548 PMID:25896339 PMID:27454768
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; [Lipopolysaccharides co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Quercetin] results in increased expression of HMOX1 protein; [Quercetin co-treated with Hypochlorous Acid] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; AG 1879 inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Cycloheximide inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Quercetin results in increased expression of HMOX1 protein]; herbimycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; NFE2L2 protein affects the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; pyrazolanthrone promotes the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; Quercetin affects the reaction [Dietary Fats affects the expression of HMOX1 protein]; Quercetin inhibits the reaction [4-nitrophenol results in increased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in decreased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]; Quercetin inhibits the reaction [nickel sulfate results in decreased expression of HMOX1 protein]; Quercetin inhibits the reaction [TLR7 protein results in increased expression of HMOX]; Quercetin promotes the reaction [APOE gene mutant form results in increased expression of HMOX1 protein]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Quercetin analog results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]PMID:14563492 PMID:15876423 PMID:16109301 PMID:16171798 PMID:20093625 PMID:23735482 PMID:23997041 PMID:24017971 PMID:25471833 PMID:25957741 PMID:26329008 PMID:26505893 PMID:27777014 PMID:36584933
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased activity of HMOX1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with SB 203580] inhibits the reaction [Quercetin results in increased activity of HMOX1 protein]; [Paraquat co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [Quercetin co-treated with Paraquat] results in increased expression of HMOX1 protein; pyrazolanthrone inhibits the reaction [Quercetin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Quercetin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 mRNA]; Quercetin inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HMOX1 protein]; Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]; SB 203580 inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]; SB 203580 inhibits the reaction [Quercetin results in increased activity of HMOX1 protein]; SB 203580 inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; SB 203580 promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin promotes the reaction [Ethanol results in increased activity of HMOX1 protein]]]PMID:17433488 PMID:22996356 PMID:25881548 PMID:27050144 PMID:27454768
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