GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgcr | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of HMGCR mRNA | PMID:25905778 | Hmgcr | multiple interactions | EXP | | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA; [Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein; [Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein; [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA] | PMID:20696151 PMID:25240712 PMID:27488359 | Hmgcr | increases expression | ISO | Hmgcr (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of HMGCR mRNA | PMID:34896238 | Hmgcr | multiple interactions | ISO | Hmgcr (Mus musculus) | 6480464 | CTD | Acrylamide inhibits the reaction [Streptozocin results in increased expression of HMGCR mRNA] | PMID:34896238 | | ||||||||||||||||||||||
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