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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA]PMID:20519084
Hmgb1multiple interactionsISOHMGB1 (Homo sapiens)6480464CTD[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein]PMID:25412314
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