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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2753
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
Acc ID: CHEBI:16856
Term: glutathione
Definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
Chemical ID: MESH:D005978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta1affects bindingEXP 6480464CTDGlutathione binds to GSTA1 proteinPMID:10751412
Gsta1multiple interactionsEXP 6480464CTD[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione]PMID:10496977 PMID:3783048 PMID:9877184
Gsta1affects metabolic processingISOGSTA1 (Homo sapiens)6480464CTDGSTA1 protein affects the metabolism of GlutathionePMID:8886613 PMID:9084911
Gsta1multiple interactionsISOGSTA1 (Homo sapiens)6480464CTDGSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]PMID:10437668 PMID:11115505 PMID:11368548 PMID:11849043 PMID:12147362 PMID:12516103 PMID:14690442 PMID:16890185 PMID:7712478
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